(4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-Amino-3-Hydroxy-1-Oxobutan-2-Yl]-19-[[(2R)-2-Amino-3-Phenylpropanoyl]Amino]-10-[3-(Diaminomethylideneamino)Propyl]-7-[(1R)-1-Hydroxyethyl]-16-[(4-Hydroxyphenyl)Methyl]-13-(1H-Indol-3-Ylmethyl)-3,3-Dimethyl-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentazacycloicosane-4-Carboxamide (4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-氨基-3-羟基-1-氧代丁烷-2-基]-19-[[(2R)-2-氨基-3-苯基丙酰胺基]-10-[3-(二氨基甲烯氨基)丙基]-7-[1-羟乙基]-16-[4-羟基苯基甲基]-13-(1H-吲哚-3-基甲基)-3,3-二甲基-6,9,12,15,18-五氧代-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酰胺

CAS 103429-32-9 MFCD00671434

化学结构图

103429-32-9
SMILES: C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CNC3C=CC=CC=32)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CSSC(C)(C)[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@H](N)CC1C=CC=CC=1

化学属性

Mol. FormulaC51H69N13O11S2
Mol. Weight1104.30

别名和识别编码

Chemical Name(4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-Amino-3-Hydroxy-1-Oxobutan-2-Yl]-19-[[(2R)-2-Amino-3-Phenylpropanoyl]Amino]-10-[3-(Diaminomethylideneamino)Propyl]-7-[(1R)-1-Hydroxyethyl]-16-[(4-Hydroxyphenyl)Methyl]-13-(1H-Indol-3-Ylmethyl)-3,3-Dimethyl-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentazacycloicosane-4-Carboxamide
MDL NumberMFCD00671434
CAS Number103429-32-9
Synonym CTAP
PubChem Substance ID329775120
Chemical Name Translation(4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-氨基-3-羟基-1-氧代丁烷-2-基]-19-[[(2R)-2-氨基-3-苯基丙酰胺基]-10-[3-(二氨基甲烯氨基)丙基]-7-[1-羟乙基]-16-[4-羟基苯基甲基]-13-(1H-吲哚-3-基甲基)-3,3-二甲基-6,9,12,15,18-五氧代-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酰胺
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Opioid Peptides, Other Opioid Peptides, Peptides and Proteins, Peptides for Cell Biology
  • Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Opioid Peptides, Other Opioid Peptides, Peptides and Proteins, Peptides for Cell Biology
  • {SNA} Neuropeptides, Opioid Peptides, Other Opioid Peptides, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • Abbruscato, T.J., et al., Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist CTAP: comparison with morphine. J. Pharmacol. Exp. Ther. 280 , 402, (1997) 摘要
  • Bilsky, E., et al., Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH 2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. J. Pharmacol. Exp. Ther. 277 , 484, (1996) 摘要
  • Yang, Y.R., et al., Structure-activity relationships of naturally occurring and synthetic opioid tetrapeptides acting on locus coeruleus neurons. Eur. J. Pharmacol. 372 , 229-236, (1999) 摘要
  • [1]. Mitchell J Bartlett, et al. Highly-selective µ-opioid Receptor Antagonism Does Not Block L-DOPA-induced Dyskinesia in a Rodent Model.BMC Res Notes

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 储存温度:-20°C

其他信息

  • Amino Acid Sequence Phe-Cys-Tyr-Trp-Arg-Thr-Pen-Thr-NH2

系列性分类

  1. Neuropeptides - Peptides for Cell Biology
  2. Opioid Peptides - Neuropeptides
  3. Other Opioid Peptides - Opioid Peptides
  1. Opioid Peptides - Peptides for Cell Biology
  2. Other Opioid Peptides - Opioid Peptides
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Opioid Receptor  (阿片受体)

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