N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine N-(苯并[d][1,3]二氧戊环-5-基甲基)-6-氯喹唑啉-4-胺

CAS 150450-53-6 MFCD00673946

化学结构图

150450-53-6
SMILES: ClC1=CC2=C(NCC3C=C4OCOC4=CC=3)N=CN=C2C=C1

化学属性

Mol. FormulaC16H12ClN3O2
Mol. Weight313.74

别名和识别编码

Chemical NameN-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine
Synonym 4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline MBCQ
MDL NumberMFCD00673946
PubChem Substance ID329824721
Chemical Name TranslationN-(苯并[d][1,3]二氧戊环-5-基甲基)-6-氯喹唑啉-4-胺
CAS Number150450-53-6
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, New Products, Phosphodiesterase Inhibitors
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, M, Phosphodiesterase Inhibitors, 生物活性小

相关文献及参考

  • [2]. Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317(1):188-95.
  • [3]. Takeharu Kaneda, et al. Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle. J Smooth Muscle Res. 2003 Jun;39(3):47-54.
  • [1]. Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11.
  • [1]. Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11.
  • [2]. Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317(1):188-95.
  • [3]. Take

安全信息

WGK Germany3

系列性分类


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