7-Hydroxy Methotrexate 7-羟基甲氨蝶呤
CAS 5939-37-7 MFCD00674903
化学结构图
SMILES: CN(Cc1nc2c(N)nc(N)nc2[nH]c1=O)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1
化学属性
| Mol. Formula | C20H22N8O6 |
|---|---|
| Mol. Weight | 470.50 |
别名和识别编码
| Chemical Name | 7-Hydroxy Methotrexate |
|---|---|
| CAS Number | 5939-37-7 |
| Synonym | N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid 7-Hydroxy Amethopterin, 4-Amino-7-hydroxy-10-methylpteroylglutamic Acid NSC 380962 Glutamic acid, |
| MDL Number | MFCD00674903 |
| Chemical Name Translation | 7-羟基甲氨蝶呤 |
| PubChem Substance ID | 5385077 |
| InChI | InChI=1S/C20H22N8O6/c1-28(8-12-18(32)26-16-14(23-12)15(21)25-20(22)27-16)10-4-2-9(3-5-10)17(31)24-11(19(33)34)6-7-13(29)30/h2-5,11H,6-8H2,1H3,(H,24,31)(H,29,30)(H,33,34)(H5,21,22,25,26,27,32) |
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分类
- Metabolites
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A metabolite of Methotrexate, which is used as a antineoplastic and antirheumatic.
相关文献及参考
- [2]. Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43(5):1789-95.
- [1]. L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156-60.
- [1]. L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156-60.
- [2]. Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43(5):1789-95.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 37,415,1996
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