KRIBB3

CAS 129414-88-6 MFCD00710140

化学结构图

129414-88-6
SMILES: CCc1cc(-c2oncc2-c2ccc(OC)cc2)c(O)cc1OC

化学属性

Mol. FormulaC19H19NO4
Mol. Weight325.36
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameKRIBB3
Synonym 5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole KRIBB3 KRIBB3; KRIBB-3; KRIBB 3.
MDL NumberMFCD00710140
PubChem Substance ID24896001
Chemical Name Translation
FormulaC19H19NO4
IUPAC Name4-ethyl-5-methoxy-2-(4-(4-methoxyphenyl)isoxazol-5-yl)phenol
InChIKeyBNBHIGLOMVMJDB-UHFFFAOYSA-N
InChIInChI=1S/C19H19NO4/c1-4-12-9-15(17(21)10-18(12)23-3)19-16(11-20-24-19)13-5-7-14(22-2)8-6-13/h5-11,21H,4H2,1-3H3
Canonical SMILESOC1=CC(OC)=C(CC)C=C1C2=C(C3=CC=C(OC)C=C3)C=NO2
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分类

  • {SA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

产品应用

  • KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27.

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Protein Kinase Inhibitors - Kinase/Phosphatase Biology
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Protein Kinase C (PKC) - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule

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