CCT018159

CAS 171009-07-7 MFCD00710300

化学结构图

171009-07-7
SMILES: CCc1cc(-c2n[nH]c(C)c2-c2ccc3c(c2)OCCO3)c(O)cc1O

化学属性

Mol. FormulaC20H20N2O4
Mol. Weight352.38
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameCCT018159
FormulaC20H20N2O4
Synonym CCT018159; CCT-018159; CCT 018159.
IUPAC Name4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol
InChIKeyOWPMENVYXDJDOW-UHFFFAOYSA-N
InChIInChI=1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22)
Canonical SMILESOC1=C(CC)C=C(C2=NNC(C)=C2C3=CC=C4OCCOC4=C3)C(O)=C1
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产品应用

  • CCT018159 is a novel inhibitor of heat shock protein (Hsp) 90 with potential anticancer activity. CCT018159 inhibited human HSP90beta with comparable potency to 17-AAG and with similar ATP-competitive kinetics. The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. CCT018159 caused cell cytostasis associated with a G(1) arrest and induced apoptosis. CCT018159 also inhibited key endothelial and tumor cell functions implicated in invasion and angiogenesis.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. HSP
  1. Medical Research Areas
  2. Metabolism
  3. HSP

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