Fenofibric acid 非诺贝特酸

CAS 42017-89-0 MFCD00792461

化学结构图

42017-89-0
SMILES: CC(C)(OC1C=CC(=CC=1)C(=O)C1C=CC(Cl)=CC=1)C(O)=O

化学属性

Mol. FormulaC17H15ClO4
Mol. Weight319
Melting Point179.0 to 183.0 deg-C

别名和识别编码

Chemical NameFenofibric acid
CAS Number42017-89-0
Synonym A-1081 FENOFIBRIC ACID 2-[4-(4-CHLORO-BENZOYL)-PHENOXY]-2-METHYL-PROPIONIC ACID (FENOFIBRIC ACID) 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid LF 178 acid 2-[4-(4-CHLOROBENZOYL) PHENOXY]-2'-METHYL PROPANOIC ACID 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-propanoicaci 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic Acid, Procetofenic Acid 2-[4'-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
MDL NumberMFCD00792461
Beilstein Registry Number2058973
Chemical Name Translation非诺贝特酸
EC Number255-626-9
Reaxys-RN2058973
PubChem Substance ID253661146
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分类

  • Aromatics
  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {SNA} Building Blocks, Chemical Synthesis, New Products for Chemical Synthesis

产品应用

  • Fenofibric acid is the active metabolite of Fenofibrate (F248640). Increases Apolipoprotein A-I?Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transpor

相关文献及参考

  • Barter, P.J.: Arterioscler. Thromb. Vasc. Biol., 25, 1095 (2005)

安全信息

GHS Symbol
Safety Statements
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312+P330
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R50/53
RTECSUA2453000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,885,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,885,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 313 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 23(Suppl 4),S873,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1242 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year

WGK Germany3
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Hazard Codes Xn,N
Hazard Class9
UN Number 3077
Packing GroupIII

其他信息

  • MOL 文件:42017-89-0.mol
  • 用途一:用作医药中间体
  • 用途二:非诺贝特的中间体。

系列性分类


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