1H-[1,2,4]Oxadiazolo[4,3-A]Quinoxalin-1-One 1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮

CAS 41443-28-1 MFCD00792620

化学结构图

41443-28-1
SMILES: O=c1onc2cnc3ccccc3n12

化学属性

Mol. FormulaC9H5N3O2
Mol. Weight187.16
Melting Point160.0 to 164.0 deg-C

别名和识别编码

Chemical Name1H-[1,2,4]Oxadiazolo[4,3-A]Quinoxalin-1-One
CAS Number41443-28-1
Synonym ODQ
PubChem Substance ID160871480
MDL NumberMFCD00792620
Chemical Name Translation1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮
Reaxys-RN1109587
LabNetwork Molecule IDLN01307830
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Inhibitors,
  • {SNA} Cyclic Nucleotide Metabolism, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Inhibitors, Guanylyl cyclase, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,

产品应用

  • 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.

相关文献及参考

  • Lee, H.G., et al.: J. Neurosci. Res., 87 269 (2009),
  • Schrammel, et al., Characterization of 1H [1,2,4]oxadiazolo[4,3a]quinoxalin1one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol. Pharmacol. 50 , 1-5, (1996) 摘要
  • Brunner, et al., Novel guanylyl cyclase inhibitor ODQ reveals role of nitric oxidebut not of cyclic-GMP in endothelin-1 secretion. FEBS Lett. 376 , 262-266, (1995) 摘要
  • Garthwaite, et al., Potent and selective inhibition of nitric oxidesensitive guanylyl cyclase by 1H[1,2,4]oxadiazolo[4,3a]quinoxalin-1-one. Mol. Pharmacol. 48 , 184-188, (1995) 摘要
  • Vielma, A., et al., Nitric Oxide Amplifies The Rat Electroretinogram. Exp. Eye Res. 91 , 700-9, (2010) 摘要

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
RTECSRO0913150
Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Guanylyl cyclase - D to K
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Guanylyl Cyclase Inhibitors - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. G Proteins and Cyclic Nucleotides
  5. Cyclic Nucleotide Metabolism
  6. Cyclic Nucleotides and Analogs
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Glyoxalase I

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