Sulfadoxin 磺胺多辛
CAS 2447-57-6 MFCD00792890
化学结构图
SMILES:
化学属性
| Mol. Formula | C12H14N4O4S |
|---|---|
| Mol. Weight | 310 |
| Melting Point | 190-194 |
| Density | 1.441 |
别名和识别编码
| Chemical Name | Sulfadoxin |
|---|---|
| CAS Number | 2447-57-6 |
| Synonym | Sulforthomidine 4-Sulfanilamido-5,6-dimethoxypyrimidine Sulfadoxine N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide Sulfadoxine WR 4873 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide; 4-Sulfanilamido-5,6-dimethoxypyrimidine; 6-(4-Aminobenzenesulfonamide)-4,5-dimethoxypyrimidine; Sulforthomidine; Sulformethoxine |
| MDL Number | MFCD00792890 |
| PubChem Substance ID | 172089109 |
| Beilstein Registry Number | 625453 |
| EC Number | 219-504-9 |
| Chemical Name Translation | 磺胺多辛 |
| Reaxys-RN | 625453 |
| Merck Number | 8906 |
| Wiswesser Line Notation | T6N CNJ DO1 EO1 FMSWR DZ |
| LabNetwork Molecule ID | LN00241511 |
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分类
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Chemical Structure Class, Inhibits an Enzyme,
- {SNA} Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Biochemicals and Reagents, Chemical Structure Class, Folic Acid Metabolism, Inhibits an Enzyme, Mechanism of Action, Metabolic Pathways, Spectrum of Activity, Sulfonamides, 代谢组学, 细胞生物学
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Chemical Structure Class, Inhibits an Enzyme, Mechanism of Action,
- {SNA} An
产品应用
- 超长效类磺胺药物，用于治疗脑膜炎、尿路感染等。
相关文献及参考
- Kapoor, V.K., et al.: Anal. Profiles Drug Subs., 17, 571 (1988)
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P305+P351+P338+P337+P313
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,37,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
其他信息
- 遇光逐渐变色，几乎无臭。味微苦。在稀酸或碱液中易溶，丙酮中略溶，乙醇中微溶，水中几乎不溶。
- 白色或类白色结晶性粉末，遇光逐渐变色，几乎无臭。味微苦。在稀酸或碱液中易溶，丙酮中略溶，乙醇中微溶，水中几乎不溶。 熔点:195～200℃
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