CA-074 (S)-1-((2S,3S)-3-甲基-2-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-甲酰胺基)戊酰基)吡咯烷-2-羧酸

CAS 134448-10-5 MFCD00797531

化学结构图

134448-10-5
SMILES: C[C@@H](CC)[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)NCCC)C(=O)N1CCC[C@H]1C(O)=O

化学属性

Mol. FormulaC18H29N3O6
Mol. Weight383.44

别名和识别编码

Chemical NameCA-074
Synonym (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline
MDL NumberMFCD00797531
PubChem Substance ID24892580
CAS Number134448-10-5
Chemical Name Translation(S)-1-((2S,3S)-3-甲基-2-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-甲酰胺基)戊酰基)吡咯烷-2-羧酸
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分类

  • A to C, Apoptosis and Cell Cycle, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cathepsin B, Cathepsin/Granzyme Inhibitors & Substrates, Cathepsins and Granzymes, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibitors, Lysosomal Proteases, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteasome, Calpain and Lysosomal Proteases
  • {SNA} A to C, Apoptosis and Cell Cycle, Applic

相关文献及参考

  • [2]. Montaser M, et al. CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells. Biol Chem. 2002 Jul-Aug;383(7-8):1305-8.
  • [3]. Yamashima T, et al. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur J Neurosci. 1998 May;10(5):1723-33.
  • Murata, M., et al., Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro. FEBS Lett. 280 , 307, (1991) 摘要
  • [1]. Towatari T, et al. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 1991 Mar 25;280(2):311-5.
  • [1]. Towatari T, et al. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 1991 Mar 25;280(2):311-5.
  • [2]. Montaser M, et al. CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells. Biol

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

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