4-(9,10-Dihydro-4H-Benzo[4,5]Cyclohepta[1,2-B]Thiophen-4-Ylidene)-1-Methylpiperidine 4-(9,10-二氢-4H-苯并[4,5]环庚并[1,2-b]噻吩-4-亚基)-1-甲基哌啶
CAS 15574-96-6 MFCD00864192
化学结构图
SMILES: CN1CCC(CC1)=C1C2C=CC=CC=2CCC2SC=CC=21
化学属性
| Mol. Formula | C19H21NS |
|---|---|
| Mol. Weight | 295.44 |
别名和识别编码
| Chemical Name | 4-(9,10-Dihydro-4H-Benzo[4,5]Cyclohepta[1,2-B]Thiophen-4-Ylidene)-1-Methylpiperidine |
|---|---|
| CAS Number | 15574-96-6 |
| Synonym | 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine BC 105 Litec Pizotifen Pizotifen Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine Pizotyline Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine Sandomigram Sandomigran; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine Sandomygran |
| EC Number | 239-632-9 |
| MDL Number | MFCD00864192 |
| Wiswesser Line Notation | T C576 BY FS&T&J BU- DT6N DYTJ A1 |
| Beilstein Registry Number | 0753534 |
| PubChem Substance ID | 354333208 |
| Chemical Name Translation | 4-(9,10-二氢-4H-苯并[4,5]环庚并[1,2-b]噻吩-4-亚基)-1-甲基哌啶 |
| Reaxys-RN | 753534 |
| Merck Number | 7515 |
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Novartis, PI-PZ, Serotonergics, Serotonergics - Antagonists, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- Sulfur & Selenium Compounds
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
产品应用
- Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.
相关文献及参考
- [2]. Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.
- [3]. Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23(3-4):376-8.
- Geraud, G., et al.: Clin. Ther., 26, 1305 (2004),
- [1]. Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52.
- [1]. Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52.
- [2]. Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.
- [3]. Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents A
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P308+P313
- H302 Harmful if swallowed 吞食有害
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 12857 ug/kg/12D-I TOXIC EFFECTS : Liver - jaundice, other or unclassified REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 144,815,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 410 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 12,297,1970
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