(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-6-Methyl-1,11-Dioxo-1,4,4a,5,5a,6,11,12a-Octahydrotetracene-2-Carboxamide (4S,4aS,5aS,6S,12aS)-7-氯-4-(二甲氨基)-3,6,10,12,12a-五羟基-6-甲基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢并四苯-2-甲酰胺

CAS 57-62-5 MFCD00864876

化学结构图

57-62-5
SMILES: CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@](C)(O)[C@H]3C[C@@H]12

化学属性

Mol. FormulaC22H23ClN2O8
Mol. Weight478.92
Appearance 金黄色结晶性粉末，无臭，味苦。熔点168-169℃（分解）。极微溶于水，溶于盐溶液。盐酸盐微溶于甲醇、水、乙醇，不溶于丙酮、乙醚、氯仿。在空气中稳定，遇光颜色渐暗。

别名和识别编码

Chemical Name(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-6-Methyl-1,11-Dioxo-1,4,4a,5,5a,6,11,12a-Octahydrotetracene-2-Carboxamide
Synonym (4aS)-7-chloro-4c-dimethylamino-3,6t,10,12,12a-pentahydroxy-6c-methyl-1,11-dioxo-(4ar,5aξ,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide 10,12,12a-pentahydroxy-6-me 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a, 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-m 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5aα,6β,12aα)]- 4-Epimer Chlortetracycline 6-甲基-4-(二甲氨基)-3,6,10,12,12a-五羟基-1,11-二氧代-7-氯-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydrox 7-Chlorotetracycline 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-n {PubChem
MDL NumberMFCD00864876
EC Number200-341-7
CAS Number57-62-5
Chemical Name Translation(4S,4aS,5aS,6S,12aS)-7-氯-4-(二甲氨基)-3,6,10,12,12a-五羟基-6-甲基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢并四苯-2-甲酰胺
Wiswesser Line NotationL E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ M1OG RQ
PubChem Substance ID54675777
InChIInChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26-27,30,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1
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分类

  • {uni_hamburg}
  • {Chemicalbook} 饲料添加剂: 抗均促生长剂
  • {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Protein Synthesis,
  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Biochemicals and Reagents, Chemical Structure Class, Interferes with Protein Synthesis, Mechanism of Action, Media, Spectrum of Activity, Supplements, Tetracyclines, 微生物学

相关文献及参考

  • Short: III/5b Title: Structure Data of Organic Crystals: C 14 ... C 120 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5b Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover Abstract: Volume III/5 offers a compitation as complete as possible of the space groups and lattice con-stants of all crystals which have been studied by means of X-rays, neutron and electron diffraction.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

RTECSQI7750000
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany1
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition 2-8°C 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 192 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 17,497,19

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAGAAW Antimicrobial Agents Annual.  (New York, NY)  1960.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: -,595,1960

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 20,793,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mam

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 372 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   ASPHAK Archives des Sciences Physiologique.  (Paris, France)  V.1-28,
   1947-74.  Discontinued.  Volume(issue)/page/year: 23,481,1969

Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P301+P317
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • 下游产品:腺甙钴胺
  • Sigma Aldrich:57-62-5(sigmaaldrich)
  • MSDS 信息:7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide(57-62-5).msds
  • 用途三:泰乐霉素对猪痢疾，猪肺炎、猪萎缩性鼻炎，鸡慢性呼吸道病，小牛支原体引起的肺炎均有效。可用于4月龄以下的猪饲料，用量为10-50g/t,停药期5天；2月龄以下的猪饲料，用量为15-50g/t,停药期5天；也可用于鸡饲料，用量为4-50g/t,，停药期为5天，产蛋期禁用。
  • 方法二:由金色链霉菌（Streptomyces aureofacieus）发酵产生，发酵液经酸化、过滤得沉淀物，溶解于乙醇后经酸析得粗品，经溶解、成盐得盐酸盐结晶。
  • 上游原料:酵母粉
  • MOL 文件:57-62-5.mol
  • 用途四:金霉素对革兰阳性菌和阴性菌均有抑制作用，可治疗畜禽的伤寒、白痢等病。也作为也作为促进生长剂。用于猪饲料。用于10周龄以下的肉鸡饲料，用量20-50g/t，停药期7天；用于2月龄以下的猪饲料，用量为25-75g/t,停药期7天。
  • 方法一:由链霉菌（Streptomyces fradiae）发酵产生。
  • 参考质量标准二:农业部标准(暂行) 磷酸盐预混剂： 含量(标示量的)/% 85～120 外观 浅褐色粗粉 细度(过0．841mm筛)/% 90 干燥失重(60℃减压)/% ≤12.0 重金属/% ≤0.002 砷(以As计)/% ≤0.0004
  • 用途一:用作饲料添加剂、动物用药，对绝大部分革兰阳性细菌、革兰阴性细菌、立克次氏体、支原体等感染有疗效
  • 用途五:主要用于革兰氏阳性球菌和阴性杆菌的感染，亦用于斑疹伤寒、恙虫病等立克体的感染。
  • 金霉素眼膏适应症及用法:结膜炎：俗称红眼病，可先用温水清除分泌物后，涂少许本品，闭眼休息片刻，让药物充分发挥作用，1天3次，晚上临睡前再涂1次。 麦粒肿：俗称偷针眼，发病后切勿用手挤压，以避免引起其他并发症。尚未形成脓肿前，热敷疗效很好。用热毛巾热敷20分钟，接着涂金霉素 眼膏，闭眼休息片刻。一天3次。 口角糜烂：口角出现糜烂时，可服用维生素B2，同时用棉签蘸温开水清洗伤口，揩干，再抹上本品，就可加快愈合。一般三天即可好转。 疖肿：当鼻黏膜有小疖胀痛时，可用药棉蘸取金霉素眼膏涂于鼻腔处，并轻压鼻子，促使疖肿吸收，加速痊愈，其他部位的疖肿也可同样使用 。 口角及手足干裂：先用热水洗净擦干，再涂少许本品，手足部分需用胶布固定，可加快伤口愈合。
  • 参考质量标准一:参见《中华人民共和国兽药典》(以下简称《中国兽药典》)1990年版
  • 用途二:属抗生素类药
  • 方法三:该品是由金色链霉素（Streptomyces aureofacieus）的培养液中提取的广谱抗生素。
  • 概述:金霉素又称氯四环素，其盐酸盐溶于水，游离碱基特别是钙盐难溶于水。为四环素类抗生素，是在放线菌的培养液中发现的抗菌物质。可以杀 灭立克次体、支原体、衣原体、非典型分枝杆菌以及螺旋体等，适用于敏感金黄色葡萄球菌、化脓性链球菌、肺炎链球菌等革兰阳性菌及流感 嗜血杆菌等敏感革兰阴性菌所致浅表眼部感染的治疗，但同时也可用于其他部位敏感菌感染的治疗。

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Chemical Structure Class - Antibiotics
  4. Tetracyclines - Chemical Structure Class

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