Morpholine,4-((4-(2-chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4) diazepin-2-yl)-1-oxopropyl)-

CAS 105219-56-5 MFCD00865271

化学结构图

105219-56-5
SMILES: CC1=NN=C2CN=C(C3C=C(CCC(=O)N4CCOCC4)SC=3N21)C1=CC=CC=C1Cl

化学属性

Mol. FormulaC22H22ClN5O2S
Mol. Weight455.96

别名和识别编码

Chemical NameWEB2086
CAS Number105219-56-5
Synonym 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone Apafant WEB 2086BS 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine Apafant WEB 2086 WEB 2086BS WEB2086
MDL NumberMFCD00865271
Wiswesser Line NotationT B575 AN CS HN KNN GHJ D2V- AT6N DOTJ& GR BG M1
Beilstein Registry Number4302553
PubChem Substance ID329825250
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Pharmaceuticals
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, New Products, Platelet Activating Factors
  • {SNA} Bioactive Small Molecule Alphabetical Index, Lipids in Cell Signaling, Platelet Activating Factors, W, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds,

产品应用

  • Platelet activating factor (PAF) antagonist.

相关文献及参考

  • Casals-Stenzel, J., et al.: J. Pharmacol. Exp. Ther., 241, 974 (1987),
  • Adamus, W.S., et al.: Clin. Pharmacol. Ther., 47, 456 (1990),
  • Brecht, H.M., et al.: Arzneim.-Forsch., 41, 51 (1991),

安全信息

RTECSQE0479700 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4968794

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4968794

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 36 gm/kg
SEX/DURATION            : female 6-12 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 52,215,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 3250 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - abortion
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 52,209,1996

WGK Germany3

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Lipids in Cell Signaling - Cell Signaling and Neuroscience
  5. Platelet Activating Factors - Lipids in Cell Signaling

相关产品推荐