Topiramate ((3aS,5aR,8aR,8bS)-2,2,7,7-四甲基四氢-3aH-双([1,3]二恶英)〔4,5-b:4' ,5'-d]吡喃-3a-基)甲基氨基磺酸酯
CAS 97240-79-4 MFCD00865320
化学结构图
SMILES: CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
化学属性
| Mol. Formula | C12H21NO8S |
|---|---|
| Mol. Weight | 339 |
| Melting Point | 124.0 to 128.0 deg-C |
别名和识别编码
| Chemical Name | Topiramate |
|---|---|
| CAS Number | 97240-79-4 |
| Synonym | 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate 2,3:4,5-Bis-O-(1-methylethylidene)-?-D-fuctopyranose 1-Sulfamate 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate Epitoma McN 4853 RWJ 17021 TPM Topamax Topomax |
| PubChem Substance ID | 125307929 |
| MDL Number | MFCD00865320 |
| Chemical Name Translation | ((3aS,5aR,8aR,8bS)-2,2,7,7-四甲基四氢-3aH-双([1,3]二恶英)〔4,5-b:4' ,5'-d]吡喃-3a-基)甲基氨基磺酸酯 |
| Reaxys-RN | 5988957 |
| Merck Number | 9547 |
| Beilstein Registry Number | 5988957 |
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分类
- Carbohydrates & Derivatives
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Ion Channels, Ionotropic Glutamate Receptor Modulators, Johnson & Johnson, Ligand-Gated Ion Channels, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Pharmaceuticals
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Ionotropic Glutamate Receptor Modulators, Johnson & Johnson, Ligand-Gated Ion Channels, T
- Intermediates & Fine Chemicals
- {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards S - T,
产品应用
- Used as an anticonvulsant.
相关文献及参考
- [2]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.
- [3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.
- Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987),
- [1]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104.
- [1]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104.
- [2]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.
- [3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P305+P351+P338+P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,342,1989
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