Acipimox 阿西莫司

CAS 51037-30-0 MFCD00865757

化学结构图

51037-30-0
SMILES: CC1C=NC(=C[N+]=1[O-])C(O)=O

化学属性

Mol. FormulaC6H6N2O3
Mol. Weight154.13
Melting Point177-180 °C

别名和识别编码

Chemical NameAcipimox
CAS Number51037-30-0
Alfabeta NameCARBOXYMETHYLPYRAZINEOXIDE 521----
MDL NumberMFCD00865757
Synonym 2-Carboxy-5-methylpyrazine 4-oxide 2-Carboxy-5-methylpyrazine 4-oxide 5-Methylpyrazinecarboxylic acid 4-oxide 5-Methyl-2-pyrazinecarboxylic Acid 4-Oxide 5-Methyl-2-pyrazinecarboxylic acid 4-oxide 5-Methylpyrazinecarboxylic Acid 4-Oxide 5-Methylpyrazinecarboxylic acid 4-oxide Acipimox K 9321 Olbemox Olbetam
EC Number256-928-3
Reaxys-RN777471
Beilstein Registry Number25(5)4,200
Merck Number111
Chemical Name Translation阿西莫司
PubChem Substance ID135726995
Wiswesser Line NotationT6N DNJ AO B1 EVQ
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分类

  • Nutrition Research, Vitamin B, Vitamin B3, Vitamins
  • {SNA} Vitamin B, Vitamin B3, Vitamins, 生化试剂
  • {SNA} Vitamin B, Vitamin B3, Vitamins, 细胞生物学, 营养研究

产品应用

  • Antilipemic.

相关文献及参考

  • ########
  • 1. Lovisolo, P. P. et al., Pharmacological profile of a new antilipolytic agent: 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) II — Antilipolytic and blood lipid lowering activity. Pharmacol. Res. Commun. 13 , 163-174, (1981)
  • Gormsen LC, Gjedsted J, Gjedde S, et al., Free fatty acids decrease circulating ghrelin concentrations in humans. Eur. J. Endocrinol. 154 , 667-673, (2006) 摘要
  • Lucidi P, Rossetti P, Porcellati F, et al., Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis. Diabetes 59 , 1349-1357, (2010) 摘要
  • Montecucco F, Bertolotto M, et al., Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome. Am. J. Physiol. Endocrinol. Metab. 300 , E681-E690, (2011) 摘要
  • Merck 14 ,111

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P305+P351+P338+P337+P313
  • P337+P313
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H303 May be harmfully swallowed 吞食可能有害
RTECSUQ2453000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition 0-10 0-10°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 15,157,1980

Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xi
Risk Statements
  • R36 Irritating to eyes 刺激眼睛

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrazines 吡嗪
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Vitamins - Nutrition Research
  4. Vitamin B - Vitamins
  5. Vitamin B3 - Vitamin B

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