Rilmenidine 利美尼啶
CAS 54187-04-1 MFCD00865924
化学结构图
SMILES: C1COC(NC(C2CC2)C2CC2)=N1
化学属性
| Mol. Formula | C10H16N2O |
|---|---|
| Mol. Weight | 180.28 |
别名和识别编码
| Chemical Name | Rilmenidine |
|---|---|
| Wiswesser Line Notation | T5N CO AUTJ BMY- AL3TJ&- AL3TJ |
| Synonym | 2-((Dicyclopropylmethyl)imino)oxazolidine 2-(Dicyclopropylmethylamino)-2-oxazoline 2-Oxazolamine, 4,5-dihydro-N-(dicyclopropylmethyl)- Methylamine, 1,1-dicyclopropyl-N-(2-oxazolinyl)- |
| Beilstein Registry Number | 1211287 |
| CAS Number | 54187-04-1 |
| Chemical Name Translation | 利美尼啶 |
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相关文献及参考
- [2]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.
- [3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.
- [1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S.
- [1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S.
- [2]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.
- [3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#09228
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 umol/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,527,1983
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