Zileuton 齐留通

CAS 111406-87-2 MFCD00866097

化学结构图

111406-87-2
SMILES: CC(C1=CC2=CC=CC=C2S1)N(O)C(N)=O

化学属性

Mol. FormulaC11H12N2O2S
Mol. Weight236

别名和识别编码

Chemical NameZileuton
Synonym Zileuton (±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea
MDL NumberMFCD00866097
Chemical Name Translation齐留通
LabNetwork Molecule IDLN00010201
CAS Number111406-87-2
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分类

  • {SNA} Abbott, Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Lipids in Cell Signaling, Lipoxygenase
  • {SNA} Abbott, Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Lipids in Cell Signaling, Lipoxygenase, Z, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • [2]. Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner
  • [3]. Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10(3):e0121402
  • [4]. Lei C, et al. Zafirlukast attenuates advanced glycation end-products (AGEs)-induced degradation of articular extracellular matrix (ECM). Int Immunopharmacol. 2019;68:68-73.
  • [1]. Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10
  • [1]. Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10
  • [2]. Kuvibidila S, et al. Hydroxyurea and

安全信息

GHS Symbol
Precautionary statements
  • P305+P351+P338
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germany1
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xn
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Abbott - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Lipids in Cell Signaling - Cell Signaling and Neuroscience
  5. Arachidonic Acid Cascade - Lipids in Cell Signaling
  6. Enzyme Inhibitors - Arachidonic Acid Cascade
  7. Lipoxygenase - Enzyme Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Lipoxygenase  (脂氧合酶)

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