3-(3,4-Dihydroxy-5-Nitrobenzylidene)Pentane-2,4-Dione 硝替卡朋
CAS 116313-94-1 MFCD00866318
化学结构图
SMILES: CC(=O)C(=CC1=CC(O)=C(O)C(=C1)[N+]([O-])=O)C(C)=O
化学属性
| Mol. Formula | C12H11NO6 |
|---|---|
| Mol. Weight | 265.24 |
别名和识别编码
| Chemical Name | 3-(3,4-Dihydroxy-5-Nitrobenzylidene)Pentane-2,4-Dione |
|---|---|
| CAS Number | 116313-94-1 |
| Synonym | OR 462 3-((3,4-Dihydroxy-5-nitrophenyl)methylene)-2,4-pentanedione Nitecapone 3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione |
| Beilstein Registry Number | 6420063 |
| Chemical Name Translation | 硝替卡朋 |
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分类
- Aromatics
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Inhibitor for the treatment of Parkinson's disease.
相关文献及参考
- [2]. Marcocci L, et al. Nitecapone: a nitric oxide radical scavenger. Biochemistry and Molecular Biology International, 01 Oct 1994, 34(3):531-541.
- [3]. Oleg Kambur, et al. Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Eur J Pain. 2011 Aug;15(7):732-40.
- Biggs, S., et al.: Eur. J. Pharmacol., 299, 83 (1996),
- Fisher, A., et al.: Neuroscience, 95(1), 97 (2000),
- Mannisto, P., et al.: Pharmacol. Rev., 51(4), 593 (1999),
- [1]. Y J Suzuki, et al. Antioxidant properties of nitecapone (OR-462). Free Radic Biol Med. 1992 Nov;13(5):517-25.
- [1]. Y J Suzuki, et al. Antioxidant properties of nitecapone (OR-462). Free Radic Biol Med. 1992 Nov;13(5):517-25.
- [2]. Marcocci L, et al. Nitecapone: a nitric oxide radical scavenger. Biochemistry and Molecular Biology International, 01 Oct 1994, 34(3):531-541.
- [3]. Oleg Kambur, et al. Nitecapone reduces development and symptoms of neur
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 69,64,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 507 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 69,64,1991
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