Caffeic Acid Phenethyl Ester 咖啡酸苯乙酯
CAS 104594-70-9 MFCD00866470
化学结构图
SMILES: OC1C=C(/C=C/C(=O)OCCC2C=CC=CC=2)C=CC=1O
化学属性
| Mol. Formula | C17 |
|---|---|
| Mol. Weight | 284 |
| Melting Point | 127.0 to 131.0 deg-C |
别名和识别编码
| Chemical Name | Caffeic Acid Phenethyl Ester |
|---|---|
| Synonym | 3,4-Dihydroxycinnamic Acid Phenethyl Ester |
| CAS Number | 104594-70-9 |
| PubChem Substance ID | 253660271 |
| MDL Number | MFCD00866470 |
| Chemical Name Translation | 咖啡酸苯乙酯 |
| Reaxys-RN | 4752508 |
| Beilstein Registry Number | 4752508 |
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分类
- Antioxidant and Free Radical Scavengers, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Chemopreventive Agents, D to K, Enzyme Inhibi
- {SNA} Antioxidant and Free Radical Scavengers, Bioactive Small Molecule Alphabetical Index, C
相关文献及参考
- 1. Grunberger, D., et al., Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44 , 230-232, (1988) 摘要
- 2. Natarajan, K., et al., Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. U. S. A. 93 , 9090-9095, (1996) 摘要
- 3. Sud'ina, G.F., et al., Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 329 , 21-24, (1993) 摘要
- 4. Mirzoeva, O.K., and Calder, P.C., The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot. Essent. Fatty Acids 55 , 441-449, (1996) 摘要
- 5. Fesen, M.R., et al., Inhibitors of human immunodeficiency virus integrase. Proc. Natl. Acad. Sci. U. S. A. 90 , 2399-2403, (1993) 摘要
- 6. Fesen, M.R., et al., Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem. Pharmacol. 48 , 595-608, (1994) 摘要
- 7. Zheng, Z.S., et al., Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase. Oncol. Res. 7 , 445-452, (1995) 摘要
- 8. Su, Z.Z., et al., Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus-transformed rat embryo cells correlate directly with transformation progression. Cancer Res. 54 , 1865-1870, (1994) 摘要
- 9. Su, Z.Z., et al., Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells. Anticancer Res. 15 , 1841-1848, (1995) 摘要
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
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