2'-F-5-I-dU 5-碘-2'-氟脱氧尿苷

CAS 69123-98-4 MFCD00866922

化学结构图

69123-98-4
SMILES: O[C@@H]1[C@@H](F)[C@H](O[C@H]1CO)N1C=C(I)C(=O)NC1=O |&1:1,2,4,6|

化学属性

Mol. FormulaC9H10FIN2O5
Mol. Weight372
Melting Point226

别名和识别编码

Chemical Name2'-F-5-I-dU
CAS Number69123-98-4
Synonym 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione 2'-Fluoro-5-iodoarauracil 2,4(1H,3H)-Pyrimidinedione, FIAU
Beilstein Registry Number892318
Chemical Name Translation5-碘-2'-氟脱氧尿苷
Wiswesser Line NotationT6NVMVJ EI A- BT5OTJ CF DQ E1Q
MDL NumberMFCD00866922
PubChem Substance ID160871154
LabNetwork Molecule IDLN01315972
Reaxys-RN892318
Merck Number4069
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分类

  • Bases & Related Reagents
  • Nucleotides
  • Anti-virals
  • {SNA} AIDS and Viral Research Reagents, Bioactive Small Molecule Alphabetical Index, F, Immune Cell Signaling and Blood, Immune System Regulation, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Intermediates & Fine Chemicals,
  • Pharmaceuticals

产品应用

  • An antiviral agent; nucleoside analog with antihepatitis B activity.

相关文献及参考

  • Watanabe A., et al.: J. Med. Chem., 22, 21 (1979),
  • Colacino, J.M., et al.: Antimicrob. Agents Chemother., 24, 505 (1983),
  • Staschke, K.A., et al.: Antiviral Res., 23, 45 (1994),

安全信息

GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
RTECSYQ9512500 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 9100 ug/kg/13W-I
TOXIC EFFECTS :
   Liver - jaundice, other or unclassified
   Liver - liver function tests impaired
   Nutritional and Gross Metabolic - metabolic acidosis
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   333,1099,1995

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 40 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,3957,1982

WGK Germany3
Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Deoxynucleosides&Deoxynucleotides and their Analogs

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