4-(Tert-Butyl)-N-(6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-[2,2'-Bipyrimidin]-4-Yl)Benzenesulfonamide 4-(叔丁基)-N-(6-(2-羟基乙氧基)-5-(2-甲氧基苯氧基)-[2,2’-联吡啶]-4-基)苯磺酰胺

CAS 147536-97-8 MFCD00867375

化学结构图

147536-97-8
SMILES: COC1=CC=CC=C1OC1C(NS(=O)(=O)C2=CC=C(C=C2)C(C)(C)C)=NC(=NC=1OCCO)C1=NC=CC=N1

化学属性

Mol. FormulaC27H29N5O6S
Mol. Weight552

别名和识别编码

Chemical Name4-(Tert-Butyl)-N-(6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-[2,2'-Bipyrimidin]-4-Yl)Benzenesulfonamide
CAS Number147536-97-8
Synonym 4-(tert-Butyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide Monohydrate
Beilstein Registry Number \u00099031515
Chemical Name Translation4-(叔丁基)-N-(6-(2-羟基乙氧基)-5-(2-甲氧基苯氧基)-[2,2’-联吡啶]-4-基)苯磺酰胺
MDL NumberMFCD00867375
Reaxys-RN9031515
Merck Number1353
PubChem Substance ID354334055
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分类

  • Aromatics
  • Heterocycles
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.

相关文献及参考

  • [2]. Akamata K, et al. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 3;16(2):R86.
  • [3]. Iglarz M, et al. Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension. Life Sci. 2014 Nov 24;118(2):333-9.
  • [4]. Son GY, et al. Endothelin Regulates Porphyromonas gingivalis-Induced Production of Inflammatory Cytokines. PLoS One. 2016 Dec 28;11(12):e0167713.
  • Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994),
  • Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996),
  • Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996),
  • [1]. Dhillon S, et al. Bosentan:
  • [1]. Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.

安全信息

GHS Symbol
Signal word Warning
WGK Germany3
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P308+P313
  • P330 Rinse mouth. 漱口
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Endothelin Receptor  (内皮素受体)

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