Leflunomide 来氟洛米
CAS 75706-12-6 MFCD00867593
化学结构图
SMILES: [2H]C1=C(C([2H])=C([2H])C(NC(=O)C2C=NOC=2C)=C1[2H])C(F)(F)F
化学属性
| Mol. Formula | C12H9F3N2O2 |
|---|---|
| Mol. Weight | 270.21 |
| Melting Point | 153-156 |
别名和识别编码
| Chemical Name | Leflunomide |
|---|---|
| Synonym | 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide |
| MDL Number | MFCD00867593 |
| PubChem Substance ID | 160871382 |
| CAS Number | 75706-12-6 |
| Alfabeta Name | METHYLTRIFLUOROMETHYLPHENYLISOXAZOLECARBOXAMIDE N544[]()------- |
| Chemical Name Translation | 来氟洛米 |
| Beilstein Registry Number | 4323174 |
| Reaxys-RN | 4323174 |
| Merck Number | 5432 |
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信息真实价格透明
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分类
- Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Dihydroorotate dehydrogenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, L
- {SA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Dihydroorotate dehydrogenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Immune Cell Signaling and Blood,
- {SNA} D to K, Dihydrooro
相关文献及参考
- [2]. Xu X, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270(21):12398-403.
- [3]. Fox RI, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208.
- 1. Leca, N., Leflunomide use in renal transplantation Curr. Opin. Organ Transplant. 14 , 370-374, (2009) 摘要
- 2. Kremer, J.M., and Cannon, G.W., Benefit/risk of leflunomide in rheumatoid arthritis Clin. Exp. Rheumatol. 22 , S95-100, (2004) 摘要
- Brazelton, T.R., and Morris, R.E. Curr. Opin. Immunol. 8 , 710, (1996) 摘要
- Di Stefano, A.B., et al., Survivin Is Regulated By Interleukin-4 In Colon Cancer Stem Cells. J. Cell Physiol. 225 , 555-61, (2010) 摘要
- Merck 14 ,5432
- Siemasko, K.F. Transplantation 61 , 635, (1996) 摘要
- Xu, X., et al. Biochem. Pharmacol. 52 , 527, (1996) 摘要
- Xu, X., et al. J. Immunol. 159 , 167, (1997) 摘
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P301+P310+P330
- P305+P351+P338
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H301 Toxic if swallowed 吞食有毒
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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