Gestodene 孕二烯酮

CAS 60282-87-3 MFCD00867858

化学结构图

60282-87-3
SMILES: CC[C@@]12CC[C@H]3[C@@H]4CCC(=O)C=C4CC[C@@H]3[C@H]1CC[C@]2(O)C#C |&1:2,5,6,15,16,19|

化学属性

Mol. FormulaC21H26O2
Mol. Weight310

别名和识别编码

Chemical NameGestodene
CAS Number60282-87-3
Synonym (17)-13-Ethyl-17-hydroxy-18,19-Dinorpregna-4,15-dien-20-yn-3-one, Gestinol, SHB 331, WL 70 (17?)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one (17α)-13-Ethyl-17-hydroxy-18,19-Dinorpregna-4,15-dien-20-yn-3-one Gestinol SHB 331 WL 70 (17α)-13-Ethyl-17-hydroxy-18,19-Dinorpregna-4,15-dien-20-yn-3-one, Gestinol, SHB 331, WL 70 17-alpha-Ethinyl-13-ethyl-17-beta-hydroxy-4,15-gonadien-3-one SH B 331 SHB 331 WL 70
MDL NumberMFCD00867858
EC Number262-145-8
Chemical Name Translation孕二烯酮
Beilstein Registry Number4237181
PubChem Substance ID329825299
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, New Products, Progesterone, Steroid Hormones
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Progesterone, Steroid Hormones
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, G, Hormones, Progesterone, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive.

相关文献及参考

  • Duesterberg, B., et al.: Contraception, 24, 673 (1981),
  • Duesterberg, B., et al.: Seroids, 43, 43 (1984),
  • Losert, W., et al.: Arzneim.-Forsch., 35, 459 (1985),
  • Seeger, H., et al., The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells. Horm. Metab. Res. 35 , 76-80, (2003)
  • Iqbal, M.J., and Colletta, A.A., Characterisation of gestodene binding to the oestrogen receptor in human malignant breast tissue. Anticancer Res. 7 , 45-48, (1987)
  • Iqbal, J.J., et al., Differences in oestrogen receptors in malignant and normal breast tissue as identified by the binding of a new synthetic progestogen. Br. J. Cancer 54 , 447-452, (1986)

安全信息

GHS Symbol
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word Warning
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xn
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
RTECSJF7956000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 35,459,1985

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Progesterone - Steroid Hormones

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