Limaprost

CAS 74397-12-9 MFCD00868275

化学结构图

74397-12-9
SMILES: C[C@H](C[C@H](O)/C=C/[C@@H]1[C@@H](CCCC/C=C/C(O)=O)C(=O)C[C@H]1O)CCCC

化学属性

Mol. FormulaC22H36O5
Mol. Weight381

别名和识别编码

Chemical NameLimaprost
CAS Number74397-12-9
Synonym (2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic Acid (2E,11-alpha,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprost-2,13-dien-1-oic acid (2E,11?,13E,15S,17S)-11,15-Dihydroxy-17,20- 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid 17α,20-dimethyl-δ2-PGE1 17S,20-Dimethyl-trans-2,3-didehydro-PGE1 17α,20-dimethyl-δ2-PGE1 9-Oxo-11-alpha,15-alpha-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic acid Limaprost ONO 1206 OP 1206
MDL NumberMFCD00868275
PubChem Substance ID329817640
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Pharmaceuticals
  • Chiral Reagents
  • {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Lipids in Cell Signaling, Prostaglandins
  • Intermediates & Fine Chemicals,
  • {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, L, Lipids in Cell Signaling, Prostaglandins, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.

相关文献及参考

  • Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980),
  • Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981),
  • Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
Hazard statements
  • H300 Fatal if swallowed 吞食致命
RTECSUK8362500
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2041368

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2041368

系列性分类


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