Alfacalcidol 阿法骨化醇
CAS 41294-56-8 MFCD00868328
化学结构图
SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@@H](O)C[C@H](O)C/1=C
化学属性
| Mol. Formula | C27H44O2 |
|---|---|
| Mol. Weight | 400.63706 |
| Melting Point | 134.0 to 138.0 deg-C |
别名和识别编码
| Chemical Name | Alfacalcidol |
|---|---|
| Synonym | 1α-Hydroxycholecalciferol Alfacalcidol 1α-Hydroxyvitamin D3 |
| MDL Number | MFCD00868328 |
| PubChem Substance ID | 354335206 |
| EC Number | 255-297-1 |
| Reaxys-RN | 2064794 |
| Merck Number | 4819 |
| Chemical Name Translation | 阿法骨化醇 |
| Formula | C27H44O2 |
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分类
- {SNA} Metabolic Pathways, Metabolomics, Nutrition Research, Steroid Metabolism, Vitamin D, Vitamin D3, Vitamins
- {SNA} Vitamin D, Vitamins, 代谢组学, 代谢通路, 固醇代谢, 生化试剂, 细胞生物学
- {SNA} Vitamin D, Vitamin D3, Vitamins, 代谢组学, 代谢通路, 固醇代谢, 细胞生物学, 营养研究
产品应用
- Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism.
安全信息
GHS Symbol
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P310
- P301+P310+P330
- P302+P350
- P302+P352+P310+
- P302+P352+P310+P361+P364
- P304+P340+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H300 Fatal if swallowed 吞食致命
- H300+H310+H330
- H310 Fatal in contact with skin 皮肤接触致命
- H330 Fatal if inhaled 吸入致命
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
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