Aflatoxin B1, crystalline 黄曲霉素B1

CAS 1162-65-8 MFCD00869647

化学结构图

1162-65-8
SMILES: COc1cc2c(c3oc(=O)c4c(c13)CCC4=O)C1C=COC1O2

化学属性

Mol. FormulaC17H12O6
Mol. Weight312
Density1.422
Melting Point268-269
SolubilityMay be dissolved in DCM, DMSO or Methanol
Stability对光线敏感

别名和识别编码

Chemical NameAflatoxin B1, crystalline
CAS Number1162-65-8
Synonym {uni_hamburg} Aflatoxin B1 (form 1) (-)-Aflatoxin B1 Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6aα,9aα-tetrahydro-4-methoxy- AFBI Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)- 黄曲霉素 B1 溶液 2,3,6a-α,9a-α-tetrahydro-4-methoxycyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a, 9a-tetrahydro-4-methoxy-, (6aR-cis)- Aflatoxin B1 黄曲霉素 B1 来源于黄曲霉 Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR,9aS)- Aflatoxin B1 (form 2) (7ar-cis)-10a-tetrahydro-5-methoxy Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6aα, 9aα-tetrahydro-4-methoxy- NSC 529592 AFB1 1-Cyclopentene-1-carboxylic acid, 2-(3a,8a-dihydro-4-hydroxy-6-methoxyfuro[2,3-b]benzofuran-5-yl)-5-oxo-, δ-lactone Standardaflatoxin® B1 (6aR,9aS)-2,3,6a,9a-Tetrahydro-4-methoxy-1H,11H-cyclopenta[c]furo[3?,2?:4,5]furo[2,3-h][1]benzopyran-1,11-dione Aflatoxin b(1) 2,3,6aα,9aα-tetrahydro-4-methoxycyclopenta[c]furo[2',3':4,5]furo[2,3-h]chromene-1,11-dione
PubChem Substance ID186907
EC Number214-603-3
Beilstein Registry Number1269174
MDL NumberMFCD00869647
Chemical Name Translation黄曲霉素B1
LabNetwork Molecule IDLN01273781
InChIInChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
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分类

  • {SNA} A,
  • {SNA} A, AA to AL, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Biotoxins, Chromatography,
  • {SNA} A-AM, Application Index, Bioactive Small Molecule Alphabetical Index, Carcinogens, Cell Signaling Enzymes, Mold, Neurobiology, Neuroscience, Pharmacologicals, Substrates, Toxins, Toxins and Venoms, Xenobiotics and Drug Metabolism, 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学,
  • {SNA} All alphabetically sorte

产品应用

  • Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.

相关文献及参考

  • [2]. Aguilar F, et al. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8586-90.
  • Beil. 19 ,V,10,566
  • Cifford, R., et al.: Nature, 209, 312 (1966),
  • Manson MM, et al. Carcinogenesis 18 , 1729-38, (1997) 摘要
  • Merck 14 ,180
  • Pei, S., et al., Using HTS-ELISA method to make anti-aflatoxin M1 monoclonal antibody Wei Sheng Wu Xue Bao 50 , 1406-11, (2010)
  • Piekkola, S., et al., Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 29(6) , 962-71, (2012)
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publis

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 6.1 F,T F,Xn T+
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302+H312+H332
  • H350 May cause cancer 可能致癌
  • H300+H310+H330
  • H370 Causes damage to organs 导致器官损伤
  • H331 Toxic if inhaled 吸入中毒
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H332 Harmful if inhaled 吸入有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
RTECSGY1925000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P302+P350
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R45 May cause cancer 可能致癌
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
Packing GroupI
UN Number 2811
Storage condition 贮存温度2-8℃

其他信息

  • Aflatoxin B1 is a potent hepatotoxic and hepatocarcinogenic mycotoxin. It is also mutagenic, teratogenic, and causes immunosuppression in animals. Aflatoxins are produced by several species of Aspergillus besides A. flavus
  • A potent hepatotoxic and hepatocarcinogenic mycotoxin
  • Aflatoxin B1 is a potent hepatotoxic and hepatocarcinogenic mycotoxin. It is also mutagenic, teratogenic, and causes immunosuppression in animals.

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  1. Life Science 生命科学
  2. Cancer Research
  3. Carcinogens - Cancer Research
  1. Life Science 生命科学
  2. Cancer Research
  3. Carcinogens - Cancer Research
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Xenobiotics and Drug Metabolism - Cell Signaling Enzymes
  7. Substrates - Xenobiotics and Drug Metabolism
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. A - Alphabetic
  5. AA to AL - A
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Biotoxins - Life Sciences Standards
  6. Mycotoxins - Biotoxins
  7. Single component solutions - Mycotoxins
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Biotoxins - Life Sciences Standards
  6. Mycotoxins - Biotoxins
  7. Alphabetical sorted - Mycotoxins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Toxins and Venoms
  5. Fish
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Xenobiotics and Drug Metabolism
  6. Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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