Propanoic acid, 2,2-dimethyl-, 1,1'-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester 9-[2-[双(新戊酰氧基)甲氧基]磷酰甲氧基]乙基-腺嘌呤

CAS 142340-99-6 MFCD00869897

化学结构图

142340-99-6
SMILES: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2C(N)=NC=NC1=2)OCOC(=O)C(C)(C)C

化学属性

Mol. FormulaC20H32N5O8P
Mol. Weight501.48
Melting Point99.0 to 103.0 deg-C

别名和识别编码

Chemical NamePropanoic acid, 2,2-dimethyl-, 1,1'-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester
CAS Number142340-99-6
Synonym Adefovir dipivoxil bis(POM)-PMEA 2,2-Dimethyl-propanoic Acid 1,1'-[[[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] Ester 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine Preveon Hepsera
MDL NumberMFCD00869897
LabNetwork Molecule IDLN01282077
Chemical Name Translation9-[2-[双(新戊酰氧基)甲氧基]磷酰甲氧基]乙基-腺嘌呤
Reaxys-RN7060608
PubChem Substance ID135727110
Merck Number151
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分类

  • Bases & Related Reagents
  • Nucleotides
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Antibiotics, Antiviral, Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides, Spectrum of Activity
  • {SNA} Antiviral, Nucleoside Analogs, Spectrum of Activity, 抗生素, 核苷，核苷酸和寡核苷酸, 生化试剂

产品应用

  • A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI).

相关文献及参考

  • Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),
  • Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),
  • Ming, X., et al.: Biochem. Pharmacol., 79, 455 (2010),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xn
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
RTECSUA2459362
Storage condition <0°C

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Functional Group 官能团索引
  2. phosphonic acid derivative
  1. Functional Group 官能团索引
  2. phosphonic acid ester

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