(2R,3R,4S,5R)-5-(6-Amino-2-Chloro-9H-Purin-9-Yl)-4-Fluoro-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol (2R,3R,4S,5R)-5-(6-氨基-2-氯-9H-嘌呤-9-基)-4-氟-2-(羟甲基)四氢呋喃-3-醇

CAS 123318-82-1 MFCD00871077

化学结构图

123318-82-1
SMILES: NC1=NC(Cl)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F

化学属性

Mol. FormulaC10H11ClFN5O3
Mol. Weight304
TSCANo

别名和识别编码

Chemical Name(2R,3R,4S,5R)-5-(6-Amino-2-Chloro-9H-Purin-9-Yl)-4-Fluoro-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol
CAS Number123318-82-1
Synonym (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (2R,3R,4S,5R)​-​5-​(6-​amino-​2-​chloropurin-​9-​yl)​-​4-​fluoro-​2-​(hydroxymethyl)​oxolan-​3-​ol, 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine 2-Chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine C1-F-Ara-A Clofarabine
MDL NumberMFCD00871077
Merck Number2372
PubChem Substance ID135727330
Chemical Name Translation(2R,3R,4S,5R)-5-(6-氨基-2-氯-9H-嘌呤-9-基)-4-氟-2-(羟甲基)四氢呋喃-3-醇
Reaxys-RN4882539
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分类

  • Bases & Related Reagents
  • Nucleotides
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, Fluorination Ready Pharma-Developed Compounds, Sanofi Aventis, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Sanofi Aventis

产品应用

  • Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.

相关文献及参考

  • Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003),
  • Kantarjian, H., et al.: Blood, 102, 2379 (2003),
  • Faderl, S., et al.: Cancer, 103, 1985 (2005),

安全信息

GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
Hazard statements
  • H300 Fatal if swallowed 吞食致命
WGK Germany2
Signal word Danger
RTECSUD7473000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Hazard Codes 6.1 T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
Packing GroupIII
UN Number 2811 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 50 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   51,2386,1991

Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. CI-CY - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Sanofi Aventis - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inhibitors - Apoptosis and Cell Cycle
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物

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