5-Ethynylpyrimidine-2,4(1H,3H)-Dione 5-乙炔基嘧啶-2,4(1H,3H)-二酮

CAS 59989-18-3 MFCD00871973

化学结构图

59989-18-3
SMILES: C#Cc1c[nH]c(=O)[nH]c1=O

化学属性

Mol. FormulaC6H4N2O2
Mol. Weight136.11
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name5-Ethynylpyrimidine-2,4(1H,3H)-Dione
CAS Number59989-18-3
Synonym 5-Ethynyl-2,4(1H,3H)-pyrimidinedione 5-Ethynyluracil 776C85; DH300004; GW776; GW-776; GW 776; GW-776C85; GW 776C85; GW776C85; NSC 687296; 5-ethynyluracil; ethynyluracil. NSC 687296
Chemical Name Translation5-乙炔基嘧啶-2,4(1H,3H)-二酮
Reaxys-RN638299
MDL NumberMFCD00871973
PubChem Substance ID253661150
Merck Number3584
FormulaC6H4N2O2
IUPAC Name5-ethynylpyrimidine-2,4(1H,3H)-dione.
InChIKeyJOZGNYDSEBIJDH-UHFFFAOYSA-N
InChIInChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)
Canonical SMILESO=C1NC(C(C#C)=CN1)=O
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分类

  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Eniluracil, also known as GW776 and GW776C85, is an orally active and irreversible inhibitor of dihydropyrimidine dehydrogenase. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil (5-FU) in the liver. Co-administration of ethynyluracil permits the oral administration of 5-FU. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

相关文献及参考

  • Morcuende, R., et al.: Clin. Translation. Oncol., 9, 459 (2007),
  • Yen-Revollo, J., et al.: Clin. Cancer Res., 14, 8 (2008),
  • Spector, T., et al.: Clin. Colorect. Cancer, 9, 52 (2010),

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Dehydrogenase

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