Trabectedin

CAS 114899-77-3 MFCD00874849

化学结构图

114899-77-3
SMILES: CN1[C@H]2CC3=CC(C)=C(OC)C(O)=C3[C@@H]1[C@@H]1[C@@H]3SC[C@]4(NCCC5C=C(O)C(=CC4=5)OC)C(=O)OC[C@@H](C4C3=C(OC(C)=O)C(C)=C3OCOC3=4)N1[C@H]2O

化学属性

Mol. FormulaC39H43N3O11S
Mol. Weight761.84

别名和识别编码

Chemical NameTrabectedin
CAS Number114899-77-3
Synonym ########
Chemical Name Translation
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信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Amines
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for pati

相关文献及参考

  • [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.
  • [3]. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44.
  • Sakai, R., et al.: Proc. Natl. Acad. Sci., 89, 11456
  • [1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.
  • [1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.
  • [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;2

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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