Itopride hydrochloride 盐酸伊托必利

CAS 122892-31-3 MFCD00881710

化学结构图

122892-31-3
SMILES: Cl.COC1=CC=C(C=C1OC)C(=O)NCC1C=CC(=CC=1)OCCN(C)C

化学属性

Mol. FormulaC20H26N2O4.HCl
Mol. Weight395
Melting Point192.0 to 196.0 deg-C

别名和识别编码

Chemical NameItopride hydrochloride
CAS Number122892-31-3
Synonym Ganaton HC-803 HSR-803 Itax Itopride hydrochloride N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4-dimethoxidebenzamide N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy Benzamide Hydrochloride N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride
MDL NumberMFCD00881710
PubChem Substance ID253662451
Chemical Name Translation盐酸伊托必利
Reaxys-RN5369226
Merck Number5244
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分类

  • {SNA} Abbott, Acetylcholinesterase, Analytical and Industrial Enzymes, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholinesterase Inhibitors, Cholinesterase and Organophosphate Detection Reagents, Dopaminargics - Antagonists, Dopaminergics, Enzyme Inhibitors, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, I, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物,

产品应用

  • Dopamine D2-receptor antagonist with anticholinesterase activity. Gastroprokinetic.

相关文献及参考

  • [2]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct;31(10):1917-22.
  • Iwanaga, Y., et al; Jpn. J. Pharmacol., 56, 261 (1991),
  • Mushiroda, T., et al.: Drug Metab. Dispos., 28, 1231 (2000),
  • [1]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8.
  • [1]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8.
  • [2]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mos

安全信息

Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
WGK Germany3
Signal word Warning
Hazard Codes 9
Risk Statements
  • R50 Very toxic to aquatic organisms 对水生生物极毒
RTECSCV4552000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 164 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995

TYPE OF TEST            : LD50 - Lethal dose, 50

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2520 mg/kg
SEX/DURATION            : male 9 week(s) pre-mating
                          female 2 week(s) pre-mating  - 7 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   18,87,1992

UN Number 3077
Packing GroupIII
Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Dopaminergics - Neurotransmitters
  8. Antagonists - Dopaminergics
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Dopamine Receptor  (多巴胺受体)

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