Iguratimod N-(7-甲基磺胺基)-4-氧代-6-苯氧基-4H-苯并吡喃-3-基)甲酰胺
CAS 123663-49-0 MFCD00882374
化学结构图
SMILES: CS(=O)(=O)Nc1cc2occ(NC=O)c(=O)c2cc1Oc1ccccc1
化学属性
| Mol. Formula | C17H14N2O6S |
|---|---|
| Mol. Weight | 374 |
| Melting Point | 238.0 to 242.0 deg-C |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO. |
别名和识别编码
| Chemical Name | Iguratimod |
|---|---|
| Chemical Name Translation | N-(7-甲基磺胺基)-4-氧代-6-苯氧基-4H-苯并吡喃-3-基)甲酰胺 |
| MDL Number | MFCD00882374 |
| Reaxys-RN | 8640145 |
| PubChem Substance ID | 253660421 |
| Formula | C17H14N2O6S |
| Synonym | N7methanesulfonamido4oxo6(phenoxy)chromen3ylformamide |
| IUPAC Name | N-(7-(methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide |
| InChIKey | ANMATWQYLIFGOK-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H14N2O6S/c1-26(22,23)19-13-8-15-12(17(21)14(9-24-15)18-10-20)7-16(13)25-11-5-3-2-4-6-11/h2-10,19H,1H3,(H,18,20) |
| Canonical SMILES | O=CNC1=COC2=C(C=C(OC3=CC=CC=C3)C(NS(=O)(C)=O)=C2)C1=O |
| CAS Number | 123663-49-0 |
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产品应用
- Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. The drug is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Iguratimod is currently under clinical trials ( http://www.simcere.com/english/r&d/Pipeline.asp).
安全信息
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P308+P313
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