Sr-12813 (2-(3,5-二叔丁基-4-羟基苯基)乙烯-1,1-二基)双(膦酸)四乙酯

CAS 126411-39-0 MFCD00888473

化学结构图

126411-39-0
SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(P(=O)(OCC)OCC)P(=O)(OCC)OCC

化学属性

Mol. FormulaC24H42O7P2
Mol. Weight504.53

别名和识别编码

Chemical NameSr-12813
Synonym SR 12813 Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate
MDL NumberMFCD00888473
PubChem Substance ID329824541
CAS Number126411-39-0
Chemical Name Translation(2-(3,5-二叔丁基-4-羟基苯基)乙烯-1,1-二基)双(膦酸)四乙酯
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholesterol and Cholesterol Metabolism, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, GlaxoSmithKline, Hydroxymethylglutaryl-CoA Reductase, Lipids in Cell Signaling, S, 生化试剂, 生物活性小分子, 甲羟戊酸途径中的抑制剂和激活剂, 癌症中的甲羟戊酸途径, 癌症代谢, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cancer Research,

相关文献及参考

  • [2]. Jiang W, et al. Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. PLoS One. 2014 Nov 26;9(11):e112632.
  • [3]. Sergio C Chai, et al. Small-molecule modulators of PXR and CAR. Biochim Biophys Acta.2016 Sep;1859(9):1141-1154.
  • [1]. Berkhout T, et al. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1996 Jun 14;271(24):14376-82.
  • [1]. Berkhout T, et al. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1996 Jun 14;271(24):14376-82.
  • [2]. Jiang W, et al. Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. PLoS One. 2014 Nov 26;9(11):e112632.
  • [3]. Sergio C Chai, e

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Lipids in Cell Signaling - Cell Signaling and Neuroscience
  5. Cholesterol and Cholesterol Metabolism - Lipids in Cell Signaling
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. GlaxoSmithKline - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Hydroxymethylglutaryl-CoA Reductase - D to K
  1. Medical Research Areas
  2. Metabolism
  3. HMG-CoA Reductase (HMGCR)  (HMG-CoA还原酶)

相关产品推荐