EPOXOMICIN 环氧甲酮四肽蛋白酶体抑制剂, 一种选择性蛋白酶体抑制剂

CAS 134381-21-8 MFCD00909008

化学结构图

134381-21-8
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化学属性

Mol. FormulaC28H50N4O7
Mol. Weight554.7000
Density1.117
Boiling Point739.2
Melting Point107-109

别名和识别编码

Chemical NameEPOXOMICIN
Chemical Name Translation环氧甲酮四肽蛋白酶体抑制剂, 一种选择性蛋白酶体抑制剂
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相关文献及参考

  • [2]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.
  • [3]. Meng L, et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10403-8.
  • [4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62.
  • [5]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82.
  • [1]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.
  • [1]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.
  • [2]. Kim KB, et

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