SB 200646 HYDROCHLORIDE 1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲盐酸盐

CAS 143797-62-0 MFCD00913519

化学结构图

143797-62-0
SMILES: Cl.CN1C=CC2=CC(=CC=C12)NC(=O)NC1C=NC=CC=1

化学属性

Mol. FormulaC15H14N4O.ClH
Mol. Weight311.77

别名和识别编码

Chemical NameSB 200646 HYDROCHLORIDE
Synonym N-(1-Methyl-1H-5-indolyl)-N′-(3-pyridinyl)urea hydrochloride
MDL NumberMFCD00913519
PubChem Substance ID24278805
Chemical Name Translation1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲盐酸盐
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分类

  • {SNA} Antagonists, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Neuroscience, Neurotransmission, Neurotransmitters, P to Q, Protein Kinase p38 MAPK, Serotonergics

相关文献及参考

  • [2]. Kennett GA, et al. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br J Pharmacol. 1994 Mar;111(3):797-802.
  • [3]. Theile JW, et al. Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons. J Pharmacol Exp Ther. 2009 May;329(2):625-33.
  • [1]. Blackburn TP, et al. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse. 2006 Jun 15;59(8):502-12.
  • [1]. Blackburn TP, et al. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse. 2006 Jun 15;59(8):502-12.
  • [2]. Kennett GA, et al. In vivo propert

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. Protein Kinase p38 MAPK - P to Q
  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)
  4. 5-HT Receptor  (5-羟色胺受体)
  5. 5-HT Receptor  (5-羟色胺受体)
  6. 5-HT Receptor  (5-羟色胺受体)
  7. 5-HT Receptor  (5-羟色胺受体)

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