Manumycin A from Streptomyces parvulus

CAS 52665-74-4 MFCD00920782

化学结构图

52665-74-4
SMILES: CC(CCCC)/C=C(\C)/C=C(\C)/C(=O)NC1=C[C@](O)(/C=C/C=C/C=C/C(=O)NC2C(=O)CCC=2O)C2OC2C1=O

化学属性

Mol. FormulaC31H38N2O7
Mol. Weight550.64

别名和识别编码

Chemical NameManumycin A from Streptomyces parvulus
MDL NumberMFCD00920782
PubChem Substance ID24897011
CAS Number52665-74-4
Synonym Manumycin A from Streptomyces parvulus
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Farnesyl transferase, Ras, G Protein Function, G Proteins and Cyclic Nucleotides, Post-translational Modification, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Farnesyl transferase, Ras, G Protein Function, G Proteins and Cyclic Nucleotides, M, Post-translational Modification
  • {SNA} Bioactive Small Molecules,

相关文献及参考

  • [2]. Bernier M, et al. Binding of manumycin A inhibits IkappaB kinase beta activity. J Biol Chem. 2006 Feb 3;281(5):2551-61.
  • [3]. Kim KH, et al. Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway. Oncol Rep. 2016 Jul;36(1):117-24.
  • [4]. Datta, A. et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in Castration resistant prostate cancer cells. Cancer Let. 408, 73–81 (2017).
  • [5]. Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.
  • Hara, M., et al. Proc. Natl. Acad. Sci. U. S. A. 90 , 2281, (1993) 摘要
  • Tamanoi, F. Trends Biochem. Sci. 18 , 349, (1993) 摘要
  • [1]. Hara M, et al. Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc Natl Acad Sci U S A. 1993 Mar

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类


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