(-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide (-)-1-(3-羟丙基)-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2,3-二氢-1H-吲哚-7-甲酰胺

CAS 160970-54-7 MFCD00930170

化学结构图

160970-54-7
SMILES: C[C@H](CC1C=C2CCN(CCCO)C2=C(C=1)C(N)=O)NCCOC1C=CC=CC=1OCC(F)(F)F

化学属性

Mol. FormulaC25H32F3N3O4
Mol. Weight495.53

别名和识别编码

Chemical Name(-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide
CAS Number160970-54-7
Synonym ########
Chemical Name Translation(-)-1-(3-羟丙基)-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2,3-二氢-1H-吲哚-7-甲酰胺
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分类

  • Amines
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • An ?1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.

相关文献及参考

  • [2]. Villa L, et al. Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters.Br J Pharmacol. 2013 May;169(1):230-8.
  • [3]. Osman NI, et al.Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.Expert Opin Pharmacother. 2012 Oct;13(14):2085-96.
  • [4]. Kawahara T, et al. Silodosin inhibits the growth of bladder cancer cells and enhances the cytotoxic activity of cisplatin via ELK1 inactivation.Am J Cancer Res. 2015 Sep 15;5(10):2959-68. eCollection 2015.
  • Murata, S., et al.: J. Urol., 164, 578 (2000),
  • Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995),
  • [1]. Maxime Rossi , Silodosin in the treatment of benign prostatic hyperplasia. Drug Des Devel Ther. 2010; 4: 291–297.
  • [1]. Maxime Rossi , Silodosin in the treatment of benign prostatic hyperplasia. Drug Des Devel Ther. 2010; 4: 291–297.
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安全信息

GHS Symbol

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

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