4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Vinyl)Benzoic Acid 4-(1-(3,5,5,8,8-五甲基-5,6,7,8-四氢-2-萘基)乙烯基)苯甲酸

CAS 153559-49-0 MFCD00932428

化学结构图

153559-49-0
SMILES: CC1C=C2C(=CC=1C(=C)C1C=CC(=CC=1)C(O)=O)C(C)(C)CCC2(C)C

化学属性

Mol. FormulaC24H28O2
Mol. Weight348
Melting Point220-225
SolubilitySoluble in DMSO and ethanol
TSCANo

别名和识别编码

Chemical Name4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Vinyl)Benzoic Acid
CAS Number153559-49-0
Synonym 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid LGD-1069 SR-11247 Bexarotene LG 100069 LG 1069 LG 69 LGD 1069 LGD-1069 RO 26-4455 SR 11247 SR-11247 Targret Targretin Targretyn Targrexin
MDL NumberMFCD00932428
Merck Number1194
Chemical Name Translation4-(1-(3,5,5,8,8-五甲基-5,6,7,8-四氢-2-萘基)乙烯基)苯甲酸
PubChem Substance ID354333139
Beilstein Registry Number7041961
Reaxys-RN7041961
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分类

  • Pharmaceuticals
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators
  • Aromatics
  • Intermediates & Fine Chemicals,
  • {SNA} B, Bioactive Small Molecule Alphabetical Index, Gene Regulation and Expression, PPAR and RXR Regulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Used as an antineoplastic. A selective retinoid X receptor (RXR) agonist.

相关文献及参考

  • [2]. Gui Y, et al. Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1. J Pain. 2019 Jan 17. pii: S1526-5900(18)30607-2.
  • [3]. Zhang X, Schlaak M, Fabri M, Mauch C, Kurschat P.
  • [4]. Orendas P, Kubatka P, Kajo K, Stollarova N, Kassayova M, Bojkova B, Pec M, Nosal V, Kiskova T, Zihlavnikova K, Karsnakova R.
  • [5]. Cras A, Politis B, Balitrand N, Darsin-Bettinger D, Boelle PY, Cassinat B, Toubert ME, Chomienne C.
  • Acta Derm Venereol. 2012 May;92(3):258-63. doi: 10.2340/00015555-1359.
  • Acta Derm Venereol. 2012 May;92(3):258-63. doi: 10.2340/00015555-1359.
  • Bexarotene via CBP/p300 induces suppression of NF-κB-dependent cell growth and invasion in thyroid cancer.
  • Bexarotene via CBP/p300 induces suppression of NF-κB-dependent cell growth and invasion in thyroid cancer.
  • Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994),
  • Case
  • Case Rep Dermatol. 2012 Jan;4(1):56-60.

安全信息

WGK Germany3
RTECSDH6834830
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
GHS Symbol
Signal word Warning
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Storage condition -20°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. PPAR and RXR Regulators - Gene Regulation and Expression
  1. Medical Research Areas
  2. Metabolism
  3. RAR/RXR  (维甲酸受体)

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