9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol,(3-beta,5Z,7E)-
CAS 55721-11-4 MFCD00941417
化学结构图
SMILES: CC(C)(O)[C@@H](O)CC[C@H](C)[C@@H]1CC[C@@H]2/C(/CCC[C@]21C)=C/C=C1/C[C@H](O)CCC/1=C |&1:4,8,10,13,18,24|
化学属性
| Mol. Formula | C27H44O3 |
|---|---|
| Mol. Weight | 417 |
别名和识别编码
| Chemical Name | (24R)-24,25-Dihydroxyvitamin D3 |
|---|---|
| Synonym | 24,25-Dihydroxyvitamin D 24,25-Dihydroxyvitamin D3 (24R)-,24,25-Dihydroxycholecalciferol Secalciferol (24R)-24,25-Dihydroxyvitamin D3 24,25-Dihydroxyvitamine D3 24,25-Dihydroxycholecalciferol |
| MDL Number | MFCD00941417 |
| PubChem Substance ID | 24850812 |
| Beilstein Registry Number | 4567039 |
| CAS Number | 55721-11-4 |
| Chemical Name Translation |
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分类
- {SNA} Metabolic Pathways, Metabolomics, Nutrition Research, Steroid Metabolism, Vitamin D, Vitamin D3, Vitamins
- {SNA} Vitamin D, Vitamin D3, Vitamins, 代谢组学, 代谢通路, 固醇代谢, 细胞生物学, 营养研究
相关文献及参考
- [2]. Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259(3):731-8.
- [3]. Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197(1-2):1-13
- [4]. Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122(4):264-71.
- [5]. Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88(1-2):110-6.
- [6]. Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr
安全信息
GHS Symbol
- P301+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- H300 Fatal if swallowed 吞食致命
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R28 Very toxic if swallowed 吞咽极毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #86-130225
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 15 ug/kg SEX/DURATION : female 16-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1945- Volume(issue)/page/year: 111,343,1981
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