Nu1025 2-甲基-8-羟基-4-喹唑啉酮

CAS 90417-38-2 MFCD00942555

化学结构图

90417-38-2
SMILES: CC1NC(=O)C2C=CC=C(O)C=2N=1

化学属性

Mol. FormulaC9H8N2O2
Mol. Weight176.17
Density1.422
Melting Point253-258

别名和识别编码

Chemical NameNu1025
CAS Number90417-38-2
Synonym 8-Hydroxy-2-methylquinazolin-4[3H]-one NSC 696807 NU-1025
MDL NumberMFCD00942555
EC Number250-023-7
Beilstein Registry Number2384789
PubChem Substance ID24724555
Chemical Name Translation2-甲基-8-羟基-4-喹唑啉酮
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分类

  • Aromatics
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cyclin-Dependent Kinase (CDK), Kinase/Phosphatase Biology, N, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclin-Dependent Kinase (CDK), Kinase/Phosphatase Biology, N, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • Inhibitors

产品应用

  • A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.

相关文献及参考

  • Griffin, R.J., et al.: J. Med. Chem., 41, 5247 (1998),
  • De Soto, J., et al.: Int. J. Biol. Sci., 2, 179 (2006),

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinazolines 喹唑啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinoxalines 喹喔啉
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Cyclin-Dependent Kinase (CDK) - Serine/Threonine Kinase Inhibitors
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Cyclin-Dependent Kinase (CDK) - Serine/Threonine Kinase Inhibitors

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