CAS 159776-70-2 MFCD00945676-美拉加群美拉加群 -LabNovo

SMILES: NC(=N)C1=CC=C(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(O)=O)C2CCCCC2)C=C1

Mol. Formula	C22H31N5O4
Mol. Weight	429.51

Chemical Name	Melagatran
CAS Number	159776-70-2
Synonym	N-[(1R)-2-[(2S)-2-[[[[4-(Aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]glycine H-319/68
Chemical Name Translation	美拉加群

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Synthetic thrombin inhibitor. Thrombin mutant anticoagulant antagonist. Antithrombotic.

[2]. Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):345-51.
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Goodman, S., et al.: J. Biomed. Mater. Res., 45, 240 (1999),
[1]. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37.
[1]. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37.
[2]. Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):3

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