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• 试剂商城
• 直接询价

分类

• Inhibitors
• Sulfur & Selenium Compounds
• {SNA} Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, Enzyme Inhibitors, Histone Deacetylase Inhibitors, Hydroxamic Acid Inhibitors, O, 分子生物学, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞生物学, 表观遗传学
• Pharmaceuticals
• {SNA} Antitumor Agents, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Cancer Research, Cell Biology, Enzyme Inhibitors, Epigenetics, Histone Deacetylase Inhibitors, Hydroxamic Acid Inhibitors, Molecular Biology, O
• Intermediates & Fine Chemicals
• Amines
• Aromatics

产品应用

• Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.

相关文献及参考

• Ohtani, M., et al.: J. Med. Chem., 39, 2871 (1996),
• Dear, A.E., et al.: Biochem. Biophys. Acta, 1492, 15 (2000),
• Lavoie, R., et al.: Bioorg. Med. Chem. Lett., 11, 2847 (2001),
• Hauke, J., et al., Survival Motor Neuron Gene 2 Silencing By DNA Methylation Correlates With Spinal Muscular Atrophy Disease Severity And Can Be Bypassed By Histone Deacetylase Inhibition. Hum. Mol. Genet. 18 , 304-17, (2009) 摘要

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