Clasto-Lactacystin .beta.-lactone

CAS 154226-60-5 MFCD01076526

化学结构图

154226-60-5
SMILES: CC(C)[C@@H]1OC(=O)[C@]21NC(=O)[C@H](C)[C@@H]2O

化学属性

Mol. FormulaC10H15NO4
Mol. Weight213.23

别名和识别编码

Chemical Nameclasto-Lactacystin β-lactone
CAS Number154226-60-5
Synonym (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione Clasto-lactacystin ?-Lactone Omuralide clasto-Lactacystin β-lactone
MDL NumberMFCD01076526
PubChem Substance ID24896450
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分类

  • {SNA} Application Index, Bioactive Small Molecule Alphabetical Index, CI-CZ, Calpain and Proteasome Inhibitors, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Inhibitors, Intracellular Protein Degradation, Nitric Oxide and Cell Stress, P to Q, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteasome inhibitor, Proteasome, Calpain and Lysosomal Proteases, Proteasomes, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} Application Index, Bioactive Small Molecules, Biochemicals and Reagents, CI-CY,
  • {SNA} Application Index,

产品应用

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相关文献及参考

  • Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997),
  • Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997),
  • Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998),
  • Craiu, A., et al., Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J. Biol. Chem. 272 , 13437-13445, (1997) 摘要
  • Dick, L.R., et al., Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells. J. Biol. Chem. 272 , 182-188, (1997) 摘要
  • Dick, L.R., et al., Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin β-lactone. J. Biol. Chem. 271 , 7273-7276, (1996) 摘要
  • Fenteany, G., et al., Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268 , 726-731, (1995) 摘要
  • Capo-chichi, C.D., et al., Loss Of GATA6 Leads To Nuclear Deformation And Aneuploidy In Ovarian Cancer. Mol. Cell. Biol. 29 , 4766-77, (2009) 摘要

安全信息

WGK Germany2
GHS Symbol
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Danger
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes T
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类


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