4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL

CAS 38214-71-0 MFCD01308792

化学结构图

38214-71-0
SMILES: CC1C=C(C(O)=CC=1)C1C=C(NN=1)C1C=CC=CC=1

化学属性

Mol. FormulaC16H14N2O
Mol. Weight250.30

别名和识别编码

Chemical NameVRT-532
Synonym 4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol 4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol CFpot 532 CFpot 532
CAS Number38214-71-0
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Chloride Channel Modulators, Ion Channels, Monovalent Ion Channels, V, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Cell Biology, Cell Signaling and Neuroscience, Chloride Channel Modulators, Ion C

相关文献及参考

  • Pasyk, S., et al., Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem. J. 18 , 185-190, (2009) 摘要
  • Van Goor, F., et al., Rescue of Delta F508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules. Am. J. Physiol. Cell Physiol. 290 , L1117-L1130, (2006) 摘要
  • Wang, Y., et al., Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J. Biol. Chem. 282 , 33247-33251, (2007)

安全信息

GHS Symbol
WGK Germany2
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger
Hazard statements
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

系列性分类


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