TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 131 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTRDI Advances in Prostaglandin and Thromboxane Research.  (New York, NY)
   V.1-8, 1976-80.  Volume(issue)/page/year: 4,157,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTRDI Advances in Prostaglandin and Thromboxane Research.  (New York, NY)
   V.1-8, 1976-80.  Volume(issue)/page/year: 4,157,1978

TYPE OF TEST            : TDLo - Lowest p

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 mg/kg
SEX/DURATION            : male 3 day(s) pre-mating
                          female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   APTRDI Advances in Prostaglandin and Thromboxane Research.  (New York, NY)
   V.1-8, 1976-80.  Volume(issue)/page/year: 4,157,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 87 ug/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   APTRDI Advances in Prostaglandin and Thromboxane Research.  (New York, NY)
   V.1-8, 1976-80.  Volume(issue)/page/year: 4,157,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 87 ug/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Fertility - abortion
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   APTRDI Advances in Prostaglandin and Thromboxane Research.  (New York, NY)
   V.1-8, 1976-80.  Volume(issue)/page/year: 4,157,1978