N-(4-(4-(Ethyl(Heptyl)Amino)-1-Hydroxybutyl)Phenyl)Methanesulfonamide Hemifumarate N-(4-(4-(乙基庚基胺)-1-羟基丁基)苯基)甲磺酰胺半富马酸盐

CAS 122647-32-9 MFCD01715410

化学结构图

122647-32-9
SMILES: CS(=O)(=O)NC1C=CC(=CC=1)C(O)CCCN(CCCCCCC)CC.CS(=O)(=O)NC1C=CC(=CC=1)C(O)CCCN(CCCCCCC)CC.OC(=O)/C=C/C(O)=O

化学属性

Mol. FormulaC20H36N2O3S.1/2C4H4O4
Mol. Weight442.62
TSCANo

别名和识别编码

Chemical NameN-(4-(4-(Ethyl(Heptyl)Amino)-1-Hydroxybutyl)Phenyl)Methanesulfonamide Hemifumarate
CAS Number122647-32-9
Synonym (±)-N-[4-(4-[Ethyl(n-heptyl)amino]-1-hydroxybutyl)phenyl]methanesulfonamide hemifumarate salt (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt Corvert (+-)-4'-(4-(Ethylheptylamino)-1-hydroxybutyl)methanesulfoanilide (+/-)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide Corvert Ibutilide hemifumarate salt
MDL NumberMFCD01715410
Merck Number4883
Chemical Name TranslationN-(4-(4-(乙基庚基胺)-1-羟基丁基)苯基)甲磺酰胺半富马酸盐
PubChem Substance ID253662069
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分类

  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, GE Healthcare, I, Ion Channels, Monovalent Ion Channels, Pfizer Compounds, Potassium Channel Modulators, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Aromatics
  • {SNA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, GE Healthcare, Ion Channels, Monovalent Ion Channels, Pfizer Compounds, Potassium Channel Modulators, Voltage-gated Ion Channels

产品应用

  • A methanesulfonanilide antiarrhythmic agent; prologns myocardial action potential duration, predominantly by activation of slow inward sodium current. Antiarrhythmic (class III).

相关文献及参考

  • Yang, T., et al.: Circulation, 91, 179 (1995),

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany1
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
RTECSPB0475700
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 94200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 49,406,1994

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 49,406,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 54,157,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - body wall
   Reproductive - Specific Developmental Abnormalities - musculoske

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 54,157,1996

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Potassium Channel Modulators - Monovalent Ion Channels

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