6-Iodo-2-Methyl-1-[2-(4-Morpholinyl)Ethyl]-1H-Indol-3-Yl](4-Methoxyphenyl)Methanone 碘代普拉朵林

CAS 164178-33-0 MFCD01861183

化学结构图

164178-33-0
SMILES: COc1ccc(C(=O)c2c(C)n(CCN3CCOCC3)c3cc(I)ccc23)cc1

化学属性

Mol. FormulaC23H25IN2O3
Mol. Weight504

别名和识别编码

Chemical Name6-Iodo-2-Methyl-1-[2-(4-Morpholinyl)Ethyl]-1H-Indol-3-Yl](4-Methoxyphenyl)Methanone
Synonym 1-(2-(morpholin-4-yl)ethyl)-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole 2-methyl-3-(4-methoxybenzoyl)-6-iodo-1-(2-morpholinoethyl)-1H-indole 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone AM 630 Iodopravadoline 6-iodopravadoline AM 630 AM-630 AM630 iodopravadoline methanone, (6-iodo-2-methyl-1-(2-(4-morpholinyl)ethyl)-1H-indol-3-yl)(4-methoxyphenyl)-
MDL NumberMFCD01861183
PubChem Substance ID4302963
Chemical Name Translation碘代普拉朵林
InChIInChI=1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
LabNetwork Molecule IDLN00189385
CAS Number164178-33-0
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分类

  • {SNA} Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, Pharmacologicals
  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Cannabinoids, Neurobiology, Neuroscience, Pharmacologicals, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • [2]. Patil, Mayur., et al. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology (2011), 61(4), 778-788.
  • [3]. Geng, D. C., et al. Inhibition of titanium particle-induced inflammatory osteolysis through inactivation of cannabinoid receptor 2 by AM630. Journal of Biomedical Materials Research, Part A (2010), 95A(1), 321-326.
  • [4]. Mukherjee, Sutapa., et al. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European Journal of Pharmacology (2004), 505(1-3), 1-9.
  • [5]. Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814.
  • [1]. Garcia-Gutierrez, Maria S., et al. Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABAA receptors. British Journal of Pharmacology

安全信息

Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
WGK Germany3
Signal word Warning
Hazard Codes N
Risk Statements
  • R50 Very toxic to aquatic organisms 对水生生物极毒

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurobiology - Neuroscience
  6. Pharmacologicals - Neurobiology
  7. Cannabinoids - Pharmacologicals
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Cannabinoid Receptor  (大麻素受体)

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