(8R,9S,10R,13S,14S,17R)-17-Acetyl-17-Hydroxy-6,10,13-Trimethyl-8,9,10,11,12,13,14,15,16,17-Decahydro-1H-Cyclopenta[A]Phenanthren-3(2H)-One 甲地孕酮

CAS 3562-63-8 MFCD01939877

化学结构图

3562-63-8
SMILES: CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C

化学属性

Mol. FormulaC22H20O3
Mol. Weight332.42

别名和识别编码

Chemical Name(8R,9S,10R,13S,14S,17R)-17-Acetyl-17-Hydroxy-6,10,13-Trimethyl-8,9,10,11,12,13,14,15,16,17-Decahydro-1H-Cyclopenta[A]Phenanthren-3(2H)-One
CAS Number3562-63-8
Synonym 17-alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione 甲地孕酮 Megestrol (base and/or unspecified salts) Megestrol 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione MEGESTROL 20-dione,17-hydroxy-6-methyl-pregna-6-diene-3 去氢甲地孕酮 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE 17-ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE
EC Number222-628-6
MDL NumberMFCD01939877
Chemical Name Translation甲地孕酮
LabNetwork Molecule IDLN01298799
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids,

产品应用

  • Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.

相关文献及参考

  • Dea-Ayuela, M., et al.: Bioorg. Med. Chem., 16, 7770 (2008),
  • Gonzalez-Diaz, H., et al.: Curr. Pharm. Des., 16, 2737 (2010),
  • Santana, L., et al.: J. Med. Chem., 51, 6740 (2008),
  • [1]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1.

安全信息

RTECSTU4074500

其他信息

  • 用途一:可治疗痛经、功能性子宫出血、子宫内膜异位及子宫内膜腺癌。
  • 下游产品:6Β-甲基孕甾-4-烯-17Α-醇-3,20-二酮-17-醋酸酯
  • MOL 文件:3562-63-8.mol

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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