Aeg 3482 6-苯基咪唑并[2,1-b][1,3,4]噻二唑-2-磺酰胺
CAS 63735-71-7 MFCD02064987
化学结构图
SMILES: NS(=O)(=O)C1=NN2C=C(N=C2S1)C1C=CC=CC=1
化学属性
| Mol. Formula | C10H8N4O2S2 |
|---|---|
| Mol. Weight | 280.33 |
别名和识别编码
| Chemical Name | Aeg 3482 |
|---|---|
| Synonym | 6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide AEG 3482 |
| MDL Number | MFCD02064987 |
| CAS Number | 63735-71-7 |
| PubChem Substance ID | 329825272 |
| Chemical Name Translation | 6-苯基咪唑并[2,1-b][1,3,4]噻二唑-2-磺酰胺 |
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分类
- Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Chaperonins and Heat Shock Proteins, Heat Shock and Related Proteins, Kinase/Phosphatase Biology, New Products, Nitric Oxide and Cell Stress, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, c-Jun N-Terminal Kinase (JNK)
- {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Heat Shock and Related Proteins, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, c-Jun N-Terminal Kinase (JNK), 一氧化氮和细胞应激, 伴侣蛋白和热休克蛋白, 生物活性小分子, 细胞信号转导和神经科学, 细胞应激,
相关文献及参考
- Ebenezer, P.J., et al., Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress. J. Alzheimers Dis. 22 , 839-848, (2010)
- Salehi, A.H., et al., AEG 3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem. Biol. 13 , 213-223, (2006)
- Gallo, K.A., et al., Targeting HSP90 to halt neurodegeneration. Chem. Biol. 13 , 115-116, (2006)
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
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