(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol (2R)-2-[[[6-[(3-氯苯基)-氨基]-9-异丙基-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇

CAS 212844-53-6 MFCD02179211

化学结构图

212844-53-6
SMILES: CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1

化学属性

Mol. FormulaC19H25ClN6O
Mol. Weight388.89
Appearance Grey to green solid powder
SolubilitySoluble in DMSO

别名和识别编码

Chemical Name(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Synonym 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine NG-60 Purvalanol A Purvalanol A, Purv; NG60; NG-60; NG 60.
MDL NumberMFCD02179211
PubChem Substance ID24898543
Chemical Name Translation(2R)-2-[[[6-[(3-氯苯基)-氨基]-9-异丙基-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇
FormulaC19H25ClN6O
IUPAC Name(R)-2-((6-((3-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol
InChIKeyPMXCMJLOPOFPBT-HNNXBMFYSA-N
InChIInChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
Canonical SMILESCC(C)[C@@H](NC1=NC(NC2=CC=CC(Cl)=C2)=C3N=CN(C(C)C)C3=N1)CO
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分类

  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin-Dependent Kinase (CDK), Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology, General Stem Cell Biology, Inhibitors, Kinase/Phosphatase Biology, PI-PZ, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Stem Cell Characterization, 干细胞生物学, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neu

产品应用

  • Purvalanol A is a potent CDK inhibitor, which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. indicating that the activation of CDKs contributes to the c-Src transformation. Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced a strong G2-M arrest, whereas PP2 weakly acted on the G1-S transition. Furthermore, when compared with PP2, purvalanol A more effectively suppressed the growth of human colon cancer HT29 and SW480 cells, in which Src family kinases and CDKs are activated.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 0 – 4 oC for short term (weeks to 1 month) or -20 oC for long terms (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Medical Research Areas
  2. Cell Cycle
  3. CDK

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