Alsterpaullone 7,12-二氢-9-硝基吲哚并[3,2-d][1]苯并氮杂卓-6(5H)-酮

CAS 237430-03-4 MFCD02683579

化学结构图

237430-03-4
SMILES: [O-][N+](=O)C1C=CC2NC3=C(CC(=O)NC4C=CC=CC=43)C=2C=1

化学属性

Mol. FormulaC16H11N3O3
Mol. Weight293.28

别名和识别编码

Chemical NameAlsterpaullone
Synonym 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one Alsterpaullone
CAS Number237430-03-4
PubChem Substance ID24890918
MDL NumberMFCD02683579
Chemical Name Translation7,12-二氢-9-硝基吲哚并[3,2-d][1]苯并氮杂卓-6(5H)-酮
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分类

  • {SNA} A to C, A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclin Dependant Kinase I, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • {SNA} A to C, A-AM, Bioactive Small Molecule Alphabetical Index, Cyclin Dependant Kinase I, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threon

相关文献及参考

  • Schultz, C., et al., Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity . J. Med. Chem. 42 , 2909, (1999) 摘要
  • Trevino, M., et al., Induction of canonical Wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella vectensis Dev. Dyn. 240 , 2673-9, (2011)
  • Kalinichev, M. and Dawson, L.A., Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania Int. J. Neuropsychopharmacol. 14 , 1051-67, (2011)
  • Takadera, T., et al., Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells Neurotox. Res. 21 , 309-16, (2012)

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类


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